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. noneImmunoglobulin therapy, also known as normal human immunoglobulin ( NHIG), is the use of a mixture of (immunoglobulins) to treat a number of health conditions. These conditions include, certain cases of and, and in certain other infections when a more specific immunoglobulin is not available.
Depending on the formulation it can be given by, a,. The effects last a few weeks.Common side effects include pain at the site of injection, muscle pain,.
Other severe side effects include,. Use is not recommended in people with some types of. Use appears to be relatively safe during. Human immunoglobulin is made from human. It contains antibodies against many.Human immunoglobulin therapy first occurred in the 1930s and a formulation for injection into a vein was approved for medical use in the United States in 1981.
It is on the, the safest and most effective medicines needed in a. Each formulation of product is somewhat different. In the United Kingdom a dose cost the between 11.20 and 1,200.00 pounds depending on the type and amount. A number of specific immunoglobulin formulations are also available including for,. Contents.Medical use Immunoglobulin therapy is used in a variety of conditions, many of which involve decreased or abolished antibody production capabilities, which range from a complete absence of multiple types of antibodies, to (usually involving IgG2 or IgG3 ), to other disorders in which antibodies are within a normal quantitative range, but lacking in quality - unable to respond to antigens as they normally should – resulting in an increased rate or increased severity of infections. In these situations, immunoglobulin infusions confer passive resistance to infection on their recipients by increasing the quantity/quality of IgG they possess.
Immunoglobulin therapy is also used for a number of other conditions, including in many autoimmune disorders such as in an attempt to decrease the severity of symptoms. Immunoglobulin therapy is also used in some treatment protocols for such as (HIV), some autoimmune disorders (such as and ), some neurological diseases (, and ) some acute infections and some complications of organ transplantation.Immunoglobulin therapy is especially useful in some acute infection cases such as infection and is also considered the standard of treatment for some autoimmune disorders such as. The American Society of Health-System Pharmacists. From the original on 9 January 2017. Retrieved 8 January 2017. ^ British national formulary: BNF 69 (69 ed.). British Medical Association.
Pp. 867–871. Etzioni, Amos; Ochs, Hans D. Academic Press. From the original on 9 January 2017. (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization.:.
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van Doorn, Pieter A.; Kuitwaard, Krista; Walgaard, Christa; van Koningsveld, Rinske; Ruts, Liselotte; Jacobs, Bart C. (16 April 2010). Journal of Clinical Immunology. 30 (S1): 74–78. Hughes, R.A.C.; Wijdicks, E.F.M.; Barohn, R.; Benson, E.; Cornblath, D.R.; Hahn, A. F.; Meythaler, J.M.; Miller, R.G.; Sladky, J.T.; Stevens, J.C. (22 September 2003).
'Practice parameter: Immunotherapy for Guillain–Barre syndrome: Report of the Quality Standards Subcommittee of the American Academy of Neurology'. 61 (6): 736–740.
Pondrom, Sue (October 2014). 'The IVIg Dilemma'. The AJT Report. American Journal of Transplantation.
14 (10): 2195–6. (PDF). National Health Service. (PDF) from the original on 29 May 2015. Retrieved 5 December 2015. (PDF).
American Association of Allergists and Immunologists. American Association of Allergists and Immunologists. (PDF) from the original on 5 March 2016. Retrieved 5 December 2015.
Anderson, David; Ali, Kaiser; Blanchette, Victor; Brouwers, Melissa; Couban, Stephen; Radmoor, Paula; Huebsch, Lothar; Hume, Heather; McLeod, Anne; Meyer, Ralph; Moltzan, Catherine; Nahirniak, Susan; Nantel, Stephen; Pineo, Graham; Rock, Gail (April 2007). 'Guidelines on the Use of Intravenous Immune Globulin for Hematologic Conditions'. Transfusion Medicine Reviews. 21 (2 Suppl 1): S9–S56. Retrieved 14 November 2019. Retrieved 14 November 2019. Retrieved 14 November 2019.
^. Dynamed Plus. EBSCO Health. From the original on 8 December 2015. Retrieved 23 November 2015. (Subscription may be required or content may be available in libraries.).
Daw, Z; Padmore, R; Neurath, D; Cober, N; Tokessy, M; Desjardins, D; Olberg, B; Tinmouth, A; Giulivi, A (August 2008). 'Hemolytic transfusion reactions after administration of intravenous immune (gamma) globulin: a case series analysis'. 48 (8): 1598–601. (PDF).
(PDF) from the original on 27 November 2015. Lichtiger, Lichtiger. Current Issues in Transfusion Medicine.
He University of Texas M. Anderson Cancer Center. From the original on 5 March 2016.
Retrieved 23 November 2015. ^ Skoda-Smith, Suzanne; Torgerson, Troy; Ochs, Hans (16 December 2009). Therapeutics and Clinical Risk Management. 2010:6: 1–10. Powell, Lynne.
Primary Immune Foundation. (PDF) from the original on 22 December 2015. Retrieved 24 November 2015. Viard I, Wehrli P, Bullani R, Schneider P, Holler N, Salomon D, Hunziker T, Saurat JH, Tschopp J, French LE (1998). 'Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin'.
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